Bioinspired Nanovesicles
A standardized, multiphysics-driven microfluidic platform, Xcycles, enabling predictable, programmable, high-yield assembly and therapeutic loading of biomimetic artificial extracellular vesicles through a structure–process–function design framework that integrates controlled multiphysical inputs with vesicle structure, function, and reproducibility for therapeutic applications.
Biomedical Acoustofluidics
The feedback-controlled acoustofluidic platform CellLEGO enables contact-free three-dimensional cultivation, manipulation, and microscopic analysis of cells and spheroids under near-physiological conditions. With precise control of perfusion and temperature, the platform can be seamlessly integrated with a wide range of microscopy modalities, allowing continuous, long-term monitoring in a microfluidic environment.
In Vivo Wearable for Theranostics
To support surgeons in continuous in vivo patient monitoring, we develop diagnostic and theranostic short-term implants.
Lab-on-a-Chip Technologies
Within CellTIVITY, we are developing a lab-on-a-chip platform applicable to multiple biomarker classes, including cells, vesicles, and proteins. The focus is on integrated end-to-end workflows combining microfluidic pumping, controlled incubation, precise magnetic manipulation, sensing, and data analysis. Targeted in-vitro diagnostic applications include quantitative magnetic flow cytometry and stochastic exosome sensing.
Live Tissue Analysis
Within CellTEST, we develop scalable, oil-free cell encapsulation methods and dedicated consumables for impedance-based 3D cell culture sensing, enabling robust, high-throughput screening of cell aggregates and spheroids.
Paper-Based Infection Diagnostics
Utilizing smart paper strips with integrated filters, the BugSense platform enables decentralized pathogen testing through controlled culturing workflows. By integrating biochemical assays, regulated incubation, and image-based image analysis, the system supports reliable, multiplexed detection of bacterial presence, pathogen identification, quantification of bacterial load, and assessment of antimicrobial resistance, for example, in point-of-care urinary tract infection diagnostics.
Quantitative Phase Imaging Flow Cytometry
By combining quantitative phase imaging, precise microfluidic flow focusing, and advanced image analysis algorithms, we develop a label-free, sample-preparation-free imaging flow cytometry platform, CellFACE, for applications in hematology, cytology, parasitology, and functional cell analysis, including the characterization of blood cell aggregates.
Telecentric Quantitative Phase Microscopy
Near-focus interference-based quantitative phase microscopy (NFI) with self-calibration properties is developed for compact, modular systems. With novel flow-focusing consumables featuring integrated Fabry-Pérot resonators, we aim to enhance the NFI contrast for next-generation sample-preparation-free hematology analyzers. The NFI is additionally supporting projects, such as CellLEGO, for tomographic applications.