Our research combines physics, engineering, and cell biology to design and control the assembly of biomimetic artificial extracellular vesicles (AEVs). Using multiphysics-driven microfluidic platforms, we precisely manipulate mechanical forces, shear flow, chaotic mixing, and acoustothermal modulation to guide membrane rupture, vesicle self-assembly, and cargo encapsulation. By linking these controlled physical inputs to biological outcomes, we establish quantitative structure–process–function relationships that reveal how vesicle morphology, membrane protein integrity, and therapeutic loading are shaped by the underlying physics.

This interdisciplinary approach facilitates the formulation of high-yield, reproducible, and functional vesicles from diverse cell types while preserving native membrane properties critical for biological targeting, immune modulation, and intercellular communication. Our work bridges fundamental biophysics with practical applications in drug delivery, gene therapy, and immunoengineering, providing standardized, scalable, and tunable platforms for translational nanomedicine. By combining rigorous physical control with biological functionality, we transform vesicle engineering from an empirical process into a predictable, programmable, and reproducible technology for next-generation biomaterials and therapeutics.

Technology Transfer

Xcycles